Epidemiologia Clinica Fletcher Pdf 31
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Using the Scopus database, a review of the keywords “vulnerable plaque”, “vulnerable atherosclerotic plaque” and “vulnerable lesion” was performed in titles, abstracts and keywords from the period from 1 January 2000 to 31 December 2018. After the removal of duplicates and articles not related to the subject of the study, we found 124 articles in the period analyzed, which were assessed independently by two reviewers and had the eligibility for inclusion in the review. After data collection and analysis, the articles were classified according to the following categories: biomarkers involved in vulnerable atherosclerotic plaque detection; markers of inflammation; lipid profile markers; markers of proteolysis; markers of oxidation; markers of oxidation and proteolysis; markers of oxidative stress; inflammatory markers; markers of endothelial dysfunction; markers of cellular stress; markers of angiogenesis; markers of extracellular matrix remodeling; and miRNAs. References were also searched, and the most recent articles were added to the review. The literature search was performed using the following Scopus keywords: “vulnerable plaque” or “vulnerable atherosclerotic plaque” or “vulnerable lesion” and “biomarker” or “marker”. The review included studies that assessed biomarkers related to vulnerable atherosclerotic plaque, including studies with and without intervention. The discussion of each category includes the biomarkers, their clinical role and their techniques of measurement. The results were organized according to these categories and subcategories. Keywords include: biomarkers of inflammation; lipid profile markers; proteolysis; markers of oxidation; markers of oxidation and proteolysis; markers of oxidative stress; inflammatory markers; markers of endothelial dysfunction; markers of cellular stress; markers of angiogenesis; markers of extracellular matrix remodeling; and miRNAs.
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